![]() In male mice, dLS GABAergic neurons, which receive glutamatergic input from hippocampal V1bR-positive neurons, inhibit neurons in the vLS, leading to. In fact, there is evidence for an intricate polysynaptic LS circuit regulating the LS-VMHvl pathway. We found that male mice mutant for the oxytocin gene (Oxt-/-) failed to develop social memory, whereas wild-type (Oxt+/+) mice showed intact social memory. As those receptors are necessary to observe several effects of nicotine including withdrawal, it is tempting to speculate that the social component of tobacco use is related to the same neuronal circuits responsible for continuing tobacco use in smokers. Social amnesia in mice lacking the oxytocin gene. The exception was A/J, a strain that demonstrated a. To determine whether CA2 activity encodes social interactions, we recorded extracellularly from CA2 pyramidal neurons (PNs) in male. Surgical procedures All surgical procedures were performed under 12 isoflurane anesthesia and with the mice mounted on a stereotaxic apparatus (SR-9M-HT Narishige, Tokyo, Japan). These social preferences were observed in both male and female mice, and in juveniles and adults. The hippocampal CA2 region is essential for social memory. We conclude that nAChRs that contain the β4 subunit are important for social behaviors. Young adult male C3H and BALB/c mice (2228 g, 68 weeks old) were used as stimulator mice. If it’s a female, they, to put it politely, initiate a whirlwind courtship. If the intruder is another male, they immediately attack it. ![]() Male mice, for example, quickly distinguish the sex of strangers infringing on what they’ve deemed their turf. In the nonsocial olfactory memory test, control littermates and β4 null mice learnt the associations to a similar extent, showing that the amnesic phenotype in the intruder test is specific for social settings. Sex-typical social behaviors have been built into animals’ brains over millions of years of evolution. Here we characterize a novel assay for social behaviors in mice contacts with anesthetized conspecific which eliminates reciprocal interactions including intermale aggression and reveals. In the intruder test, β4 null mice showed social amnesia: Wild-type mice spent less time actively interacting with a younger intruder on Day 2 than on Day 1, but β4 null mice interacted for a similar time on both days. In addition, we used a nonsocial olfactory memory test as a control. To measure social behavior, we used the intruder test for social memory in wild-type and littermate β4 null mice. In the nonsocial olfactory memory test, control littermates and 4 null mice learnt the associations to a similar. ![]() Because the β4 nicotinic receptor subunit is important for possibly related behaviors, such as anxiety-like behavior and the effects of nicotine, we studied the social behavior of mice null for the β4 nAChR subunit. Results: In the intruder test, 4 null mice showed social amnesia: Wild-type mice spent less time actively interacting with a younger intruder on Day 2 than on Day 1, but 4 null mice interacted for a similar time on both days. Therefore, nicotinic acetylcholine receptors (nAChR) may influence social behavior. Tobacco addiction has a strong social component.
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